ARDB-Antibiotic Resistance Genes Database

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Resistance Typevgbb
DescriptionStreptogramin B Lyase, which can deactivate the target drug by hydrolysis.
Antibiotic Resistancestreptogramin_b
Gene Ontology (GO)Molecular Function
lyase activity [GO:0016829]


Biological Process
streptogramin b resistance [AR:0000050]
drug enzymatic destruction [AR:0001004]
Found in GenusStaphylococcus
COGCOG4257
Description: Streptogramin lyase
Function: Defense mechanisms;

NCBI CDD33980: Vgb
Reference1) Allignet J, et al. (1998) Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.. Antimicrob Agents Chemother 42(7):1794-8 PubMed: 9661023
 PubMed: 10582867