ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanyg
Resistance Requirementvanug    vang    vanwg    vantg    vansg    vanrg    vanxyg    
DescriptionVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusEnterococcus
COGCOG1876
Description: D-alanyl-D-alanine carboxypeptidase
Function: Cell wall/membrane/envelope biogenesis;

NCBI CDD32060: VanY
140944
Reference1) McKessar SJ, et al. (2000) Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis.. Antimicrob Agents Chemother 44(11):3224-8 PubMed: 11036060
 PubMed: 16323116