ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanxyc
Resistance Requirementvanc    vansc    vanrc    vant    
DescriptionVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusEnterococcus
NCBI CDD140944
Reference PubMed: 16323116
2) Arias CA, et al. (2000) vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.. Antimicrob Agents Chemother 44(6):1660-6 PubMed: 10817725