ARDB-Antibiotic Resistance Genes Database

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Resistance Typevant
Resistance Requirementvanc    vansc    vanrc    vanxyc    
DescriptionVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusEnterococcus
NCBI CDD29547: cd00430
134067
140929
Reference1) Arias CA, et al. (1999) Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174.. Mol Microbiol 31(6):1653-64 PubMed: 10209740
 PubMed: 16323116