ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanre
Resistance Requirementvante    vanxye    vanse    vane    
DescriptionVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
teicoplanin resistance [AR:0000029]
Found in GenusEnterococcus
COGCOG745
Description: Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
Function: Signal transduction mechanisms; Transcription;

NCBI CDD29071: REC
29475: cd00383
31088: OmpR
Reference PubMed: 16323116
2) Boyd DA, et al. (2002) Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.. Antimicrob Agents Chemother 46(6):1977-9 PubMed: 12019119