ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanhd
Resistance Requirementvanrd    vansd    vand    vanxd    vanyd    
DescriptionVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
Antibiotic Resistanceteicoplanin
vancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
teicoplanin resistance [AR:0000029]
Found in GenusEnterococcus
Ruminococcus
COGCOG1052
Description: Lactate dehydrogenase and related dehydrogenases
Function: Energy production and conversion; Coenzyme transport and metabolism; General function prediction only;

NCBI CDD142332
31252: LdhA
Reference1) Casadewall B, et al. (1999) Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.. J Bacteriol 181(12):3644-8 PubMed: 10368136