ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanhb
Resistance Requirementvanxb    vanwb    vanb    vanrb    vanyb    vansb    
DescriptionVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusClostridium
Eggerthella
Enterococcus
COGCOG1052
Description: Lactate dehydrogenase and related dehydrogenases
Function: Energy production and conversion; Coenzyme transport and metabolism; General function prediction only;

NCBI CDD142332
31252: LdhA
Reference1) Evers S, et al. (1996) Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.. J Bacteriol 178(5):1302-9 PubMed: 8631706
 PubMed: 16323116