ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanc
Resistance Requirementvansc    vanrc    vant    vanxyc    
DescriptionVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusEnterococcus
NCBI CDD110791
134632
141725
Reference1) Dutka-Malen S, et al. (1992) Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance.. Gene 112(1):53-8 PubMed: 1551598
 PubMed: 16323116