ARDB-Antibiotic Resistance Genes Database

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Resistance Typevanb
Resistance Requirementvanxb    vanwb    vanrb    vanyb    vansb    vanhb    
DescriptionVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
Antibiotic Resistancevancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
Found in GenusClostridium
Eggerthella
Enterococcus
Ruminococcus
Streptococcus
COGCOG1181
Description: D-alanine-D-alanine ligase and related ATP-grasp enzymes
Function: Cell wall/membrane/envelope biogenesis;

NCBI CDD110791
134632
141725
Reference PubMed: 16323116
2) Evers S, et al. (1993) The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide-resistance proteins VanA and VanC.. Gene 124(1):143-4 PubMed: 8440477