ARDB-Antibiotic Resistance Genes Database

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Resistance Typevana
Resistance Requirementvanra    vanha    vansa    vanya    vanxa    
DescriptionVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
Antibiotic Resistanceteicoplanin
vancomycin
Gene Ontology (GO)Molecular Function
D-alanine-D-alanine ligase activity [GO:0008716]


Biological Process
drug target replacement [AR:0001002]
vancomycin resistance [AR:0000028]
teicoplanin resistance [AR:0000029]
Found in GenusBacillus
Enterococcus
Oerskovia
Paenibacillus
Staphylococcus
NCBI CDD110791
134632
141725
Reference1) Dutka-Malen S, et al. (1990) The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.. Mol Gen Genet 224(3):364-72 PubMed: 2266943
 PubMed: 16323116