ARDB-Antibiotic Resistance Genes Database

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Resistance Typetetpb
DescriptionRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.
Antibiotic Resistancetetracycline
Gene Ontology (GO)Molecular Function
translation elongation factor activity [GO:0003746]


Biological Process
drug target protection [AR:0001003]
tetracycline resistance [AR:0000051]
Found in GenusClostridium
COGCOG480
Description: Translation elongation factors (GTPases)
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD133368
58081: Tet_II
58278: cd01684
58064: Tet_C
30828: FusA
Reference PubMed: 11381101
2) Sloan J, et al. (1994) The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.. Mol Microbiol 11(2):403-15 PubMed: 8170402