ARDB-Antibiotic Resistance Genes Database

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Resistance Typetetb
DescriptionMajor facilitator superfamily transporter, tetracycline efflux pump.
Antibiotic Resistancetetracycline
Gene Ontology (GO)Molecular Function
tetracycline transporter activity [GO:0008493]


Biological Process
major facilitator superfamily (MFS) drug efflux [AR:0010002]
tetracycline resistance [AR:0000051]


Cellular Component
membrane part [GO:0044425]
Found in GenusActinobacillus
Edwardsiella
Escherichia
Haemophilus
Neisseria
Pasteurella
Pasteurellaceae
Photobacterium
Pseudomonas
Salmonella
Serratia
Shigella
Streptococcus
Vibrio
Yersinia
COGCOG2814
Description: Arabinose efflux permease
Function: Carbohydrate transport and metabolism;

COG477
Description: Permeases of the major facilitator superfamily
Function: Carbohydrate transport and metabolism; Amino acid transport and metabolism; Inorganic ion transport and metabolism; General function prediction only;

NCBI CDD32643: AraJ
119392
Reference PubMed: 11381101
2) Nguyen TT, et al. (1983) Sequence homology between the tetracycline-resistance determinants of Tn10 and pBR322.. Gene 25(1):83-92 PubMed: 6319234