ARDB-Antibiotic Resistance Genes Database

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Resistance Typetet
DescriptionRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.
Antibiotic Resistancetetracycline
Gene Ontology (GO)Molecular Function
translation elongation factor activity [GO:0003746]


Biological Process
drug target protection [AR:0001003]
tetracycline resistance [AR:0000051]
Found in GenusStreptomyces
COGCOG480
Description: Translation elongation factors (GTPases)
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD121548
58081: Tet_II
133368
58278: cd01684
58064: Tet_C
141700
121546
142557
30828: FusA
Reference PubMed: 11381101
2) Dittrich W, et al. (1992) The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.. Antimicrob Agents Chemother 36(5):1119-24 PubMed: 1510403