ARDB-Antibiotic Resistance Genes Database

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Resistance Typesmed
Resistance Requirementsmef    smee    
DescriptionResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Antibiotic Resistancefluoroquinolone
Gene Ontology (GO)Molecular Function
multidrug efflux pump activity [GO:0015559]


Biological Process
resistance-nodulation-cell division (RND) drug efflux [AR:0010004]
fluoroquinolone resistance [AR:0000026]


Cellular Component
membrane part [GO:0044425]
Found in GenusStenotrophomonas
COGCOG845
Description: Membrane-fusion protein
Function: Cell wall/membrane/envelope biogenesis;

NCBI CDD130791
Reference1) Alonso A, et al. (2000) Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia.. Antimicrob Agents Chemother 44(11):3079-86 PubMed: 11036026