ARDB-Antibiotic Resistance Genes Database

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Resistance Typepmra
DescriptionMajor facilitator superfamily transporter. Multidrug resistance efflux pump.
Antibiotic Resistanceciprofloxacin
norfloxacin
Gene Ontology (GO)Molecular Function
multidrug efflux pump activity [GO:0015559]


Biological Process
ciprofloxacin resistance [AR:0000036]
major facilitator superfamily (MFS) drug efflux [AR:0010002]
Found in GenusStreptococcus
COGCOG477
Description: Permeases of the major facilitator superfamily
Function: Carbohydrate transport and metabolism; Amino acid transport and metabolism; Inorganic ion transport and metabolism; General function prediction only;

NCBI CDD137569
119392
Reference1) Gill MJ, et al. (1999) Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.. Antimicrob Agents Chemother 43(1):187-9 PubMed: 9869592