ARDB-Antibiotic Resistance Genes Database

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Resistance Typepbp2x
DescriptionThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Antibiotic Resistancepenicillin
Found in GenusStreptococcus
COGCOG768
Description: Cell division protein FtsI/penicillin-binding protein 2
Function: Cell wall/membrane/envelope biogenesis;

NCBI CDD119325
119327
31111: FtsI
112527
141692
119326
120336
Reference1) Laible G, et al. (1989) Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506.. Mol Microbiol 3(10):1337-48 PubMed: 2615650