ARDB-Antibiotic Resistance Genes Database

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Resistance Typeoprn
Resistance Requirementmexf    mexe    
DescriptionResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Antibiotic Resistancechloramphenicol
fluoroquinolone
Gene Ontology (GO)Molecular Function
multidrug efflux pump activity [GO:0015559]


Biological Process
chloramphenicol resistance [AR:0000002]
resistance-nodulation-cell division (RND) drug efflux [AR:0010004]
fluoroquinolone resistance [AR:0000026]
Found in GenusPseudomonas
COGCOG1538
Description: Outer membrane protein
Function: Cell wall/membrane/envelope biogenesis; Intracellular trafficking, secretion, and vesicular transport;

NCBI CDD31727: TolC
Reference1) Köhler T, et al. (1997) Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.. Mol Microbiol 23(2):345-54 PubMed: 9044268