ARDB-Antibiotic Resistance Genes Database

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Resistance Typemexa
Resistance Requirementmexb    oprm    
DescriptionResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Antibiotic Resistanceaminoglycoside
beta_lactam
fluoroquinolone
tetracycline
tigecycline
Gene Ontology (GO)Molecular Function
multidrug efflux pump activity [GO:0015559]


Biological Process
tigecycline resistance [AR:0000030]
resistance-nodulation-cell division (RND) drug efflux [AR:0010004]
aminoglycoside resistance [AR:0000016]
fluoroquinolone resistance [AR:0000026]
tetracycline resistance [AR:0000051]
beta lactam resistance [AR:0000048]
Found in GenusPseudomonas
NCBI CDD137559
Reference1) Poole K, et al. (1993) Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine.. Mol Microbiol 10(3):529-44 PubMed: 7968531
2) Poole K, et al. (1993) Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon.. J Bacteriol 175(22):7363-72 PubMed: 8226684
 PubMed: 9603892
 PubMed: 8540696