ARDB-Antibiotic Resistance Genes Database

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Resistance Typemeca
DescriptionPenicillin binding protein, which has a low affinity for beta-lactams and catalyze a penicillin-insensitive transpeptidation.
Antibiotic Resistancebeta_lactam
Gene Ontology (GO)Molecular Function
peptidoglycan glycosyltransferase activity [GO:0008955]


Biological Process
beta lactam resistance [AR:0000048]
Found in GenusEnterococcus
Morganella
Staphylococcus
COGCOG768
Description: Cell division protein FtsI/penicillin-binding protein 2
Function: Cell wall/membrane/envelope biogenesis;

NCBI CDD31111: FtsI
112527
113974
120336
Reference1) Song MD, et al. (1987) Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.. FEBS Lett 221(1):167-71 PubMed: 3305073