ARDB-Antibiotic Resistance Genes Database

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Resistance Typefosc
DescriptionGlutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin
Antibiotic Resistancefosfomycin
Gene Ontology (GO)Molecular Function
glutathione transferase activity [GO:0004364]


Biological Process
fosfomycin resistance [AR:0000025]
drug enzymatic destruction [AR:0001004]
Found in GenusPseudomonas
NCBI CDD140714
Reference1) García P, et al. (1995) Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrate.. Antimicrob Agents Chemother 39(7):1569-73 PubMed: 7492106