ARDB-Antibiotic Resistance Genes Database

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Resistance Typeermq
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusClostridium
COGCOG30
Description: Dimethyladenosine transferase (rRNA methylation)
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD142332
Reference1) Berryman DI, et al. (1994) Cloning and sequence analysis of ermQ, the predominant macrolide-lincosamide-streptogramin B resistance gene in Clostridium perfringens.. Antimicrob Agents Chemother 38(5):1041-6 PubMed: 8067735