ARDB-Antibiotic Resistance Genes Database

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Resistance Typeermo
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusStreptomyces
NCBI CDD142332
Reference1) Jenkins G, et al. (1991) Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics.. Gene 108(1):55-62 PubMed: 1761231