ARDB-Antibiotic Resistance Genes Database

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Resistance Typeermb
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusArcanobacterium
Bacillus
Bacteroides
Blautia
Clostridium
Enterococcus
Escherichia
Gemella
Lactobacillus
Lactococcus
Macrococcus
Neisseria
Pediococcus
Staphylococcus
Streptococcus
NCBI CDD140359
100107
Reference1) Brehm J, et al. (1987) Sequence of the adenine methylase gene of the Streptococcus faecalis plasmid pAM beta 1.. Nucleic Acids Res 15(7):3177 PubMed: 3104884