ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfrb3
DescriptionGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAeromonas
Enterobacter
Escherichia
Klebsiella
NCBI CDD115119
Reference1) Flensburg J, et al. (1986) Nucleotide sequence analysis of the trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751.. Nucleic Acids Res 14(14):5933 PubMed: 3526286
 PubMed: 11432417