ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Resistance Typedfrb2
DescriptionGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusEscherichia
Pseudomonas
NCBI CDD115119
Reference1) Zolg JW, et al. (1981) Characterization of a R plasmid-associated, trimethoprim-resistant dihydrofolate reductase and determination of the nucleotide sequence of the reductase gene.. Nucleic Acids Res 9(3):697-710 PubMed: 6261228
 PubMed: 11432417