ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Resistance Typedfra7
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAcinetobacter
Escherichia
Klebsiella
Proteus
Salmonella
Shigella
NCBI CDD29264: DHFR
Reference1) Sundström L, et al. (1993) Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance.. J Bacteriol 175(6):1796-805 PubMed: 8383666
 PubMed: 11432417