ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Resistance Typedfra5
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAeromonas
Enterobacter
Escherichia
Klebsiella
Salmonella
Vibrio
NCBI CDD29264: DHFR
Reference1) Sundström L, et al. (1988) Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21.. Mol Gen Genet 213(2-3):191-201 PubMed: 3054482
 PubMed: 11432417