ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra22
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusEscherichia
Klebsiella
NCBI CDD29264: DHFR
Reference1) Grape M, et al. (2005) Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria.. Clin Microbiol Infect 11(3):185-92 PubMed: 15715715
 PubMed: 11432417