ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra19
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusEnterobacter
Klebsiella
Salmonella
NCBI CDD29264: DHFR
Reference1) Tosini F, et al. (1998) Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.. Antimicrob Agents Chemother 42(12):3053-8 PubMed: 9835490
 PubMed: 11432417