ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra15
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusEnterobacter
Escherichia
Klebsiella
Morganella
Proteus
Pseudomonas
Salmonella
Vibrio
NCBI CDD29264: DHFR
Reference1) Adrian PV, et al. (1998) New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.. Antimicrob Agents Chemother 42(9):2221-4 PubMed: 9736538
 PubMed: 11432417