ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra14
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAchromobacter
Aeromonas
Escherichia
Klebsiella
Salmonella
Vibrio
NCBI CDD29264: DHFR
Reference1) Young HK, et al. (1994) Nucleotide sequence and genetic analysis of the type Ib trimethoprim-resistant, Tn4132-encoded dihydrofolate reductase.. J Antimicrob Chemother 34(5):715-25 PubMed: 7706167
 PubMed: 11432417