ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra13
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusEscherichia
NCBI CDD29264: DHFR
Reference1) Adrian PV, et al. (2000) New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron.. Antimicrob Agents Chemother 44(2):355-61 PubMed: 10639362
 PubMed: 11432417