ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra12
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAcinetobacter
Aeromonas
Citrobacter
Enterococcus
Escherichia
Klebsiella
Pseudomonas
Salmonella
Serratia
Shigella
Staphylococcus
Vibrio
NCBI CDD29264: DHFR
Reference1) Heikkilš E, et al. (1993) A novel dihydrofolate reductase cassette inserted in an integron borne on a Tn21-like element.. Antimicrob Agents Chemother 37(6):1297-304 PubMed: 8392309
 PubMed: 11432417