ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra10
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAcinetobacter
Escherichia
Klebsiella
Salmonella
NCBI CDD29264: DHFR
Reference1) Hall RM, et al. (1987) The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons.. Nucleic Acids Res 15(18):7491-501 PubMed: 2821509
 PubMed: 11432417