ARDB-Antibiotic Resistance Genes Database

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Resistance Typedfra1
DescriptionGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Antibiotic Resistancetrimethoprim
Gene Ontology (GO)Molecular Function
dihydrofolate reductase activity [GO:0004146]


Biological Process
trimethoprim resistance [AR:0000010]
Found in GenusAcinetobacter
Aeromonas
Aliivibrio
Bordetella
Citrobacter
Enterobacter
Escherichia
Klebsiella
Morganella
Proteus
Providencia
Pseudomonas
Psychrobacter
Raoultella
Riemerella
Salmonella
Serratia
Shigella
Vibrio
NCBI CDD29264: DHFR
Reference1) Fling ME, et al. (1983) The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7.. Nucleic Acids Res 11(15):5147-58 PubMed: 6308574
 PubMed: 11432417