ARDB-Antibiotic Resistance Genes Database

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Resistance Typecata3
DescriptionGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Antibiotic Resistancechloramphenicol
Gene Ontology (GO)Molecular Function
chloramphenicol O-acetyltransferase activity [GO:0008811]


Biological Process
chloramphenicol resistance [AR:0000002]
drug enzymatic destruction [AR:0001004]
Found in GenusActinobacillus
Bibersteinia
Edwardsiella
Escherichia
Klebsiella
Mannheimia
Shigella
COGCOG4845
Description: Chloramphenicol O-acetyltransferase
Function: Defense mechanisms;

NCBI CDD141349
Reference1) Leslie AG, et al. (1986) Crystallization of a type III chloramphenicol acetyl transferase.. J Mol Biol 188(2):283-5 PubMed: 3522921