ARDB-Antibiotic Resistance Genes Database

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Resistance Typecata1
DescriptionGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Antibiotic Resistancechloramphenicol
Gene Ontology (GO)Molecular Function
chloramphenicol O-acetyltransferase activity [GO:0008811]


Biological Process
chloramphenicol resistance [AR:0000002]
drug enzymatic destruction [AR:0001004]
Found in GenusAchromobacter
Acinetobacter
Aeromonas
Alphabaculovirus
Bacillus
Bifidobacterium
Brugia
Corynebacterium
Dictyostelium
Escherichia
Eubacterium
Klebsiella
Neisseria
Neurospora
other sequences
Photobacterium
Pseudomonas
Salmonella
Serratia
Shigella
Simplexvirus
Yersinia
COGCOG4845
Description: Chloramphenicol O-acetyltransferase
Function: Defense mechanisms;

NCBI CDD141349
Reference1) Shaw WV, et al. (1972) Hybridization of variants of chloramphenicol acetyltransferase specified by fi + and fi - R factors.. Proc Natl Acad Sci U S A 69(10):3049-53 PubMed: 4628098