ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl2f_sme1
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecarbapenem
cephalosporin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusSerratia
NCBI CDD141062
Reference1) Naas T, et al. (1994) Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6.. Antimicrob Agents Chemother 38(6):1262-70 PubMed: 8092824