ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl2c_pse1
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecarbenicillin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAchromobacter
Acinetobacter
Burkholderia
Escherichia
Klebsiella
Morganella
Pasteurella
Proteus
Pseudomonas
Salmonella
Vibrio
NCBI CDD141062
Reference1) Boissinot M, et al. (1990) Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with the Staphylococcus aureus PC1 beta-lactamase crystal structure.. J Biol Chem 265(2):1225-30 PubMed: 2295609