ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl2be_shv2
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancee_cephalosporin
monobactam
n_cephalosporin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAcinetobacter
Citrobacter
Cronobacter
Enterobacter
Enterococcus
Escherichia
Klebsiella
Proteus
Pseudomonas
Raoultella
Salmonella
Shigella
Yersinia
NCBI CDD141062
Reference1) Arakawa Y, et al. (1986) Close evolutionary relationship between the chromosomally encoded beta-lactamase gene of Klebsiella pneumoniae and the TEM beta-lactamase gene mediated by R plasmids.. FEBS Lett 207(1):69-74 PubMed: 3533626