ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl2be_per
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancee_cephalosporin
monobactam
n_cephalosporin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAcinetobacter
Aeromonas
Alcaligenes
Citrobacter
Escherichia
Proteus
Providencia
Pseudomonas
Salmonella
NCBI CDD141062
Reference1) Nordmann P, et al. (1994) Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases.. Antimicrob Agents Chemother 38(1):104-14 PubMed: 8141562