ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Resistance Typebl2b_tem1
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecephalosporin_i
cephalosporin_ii
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAcetobacter
Acinetobacter
Citrobacter
Cronobacter
Enterobacter
Escherichia
Haemophilus
Helicobacter
Inovirus
Klebsiella
Neisseria
other sequences
P1-like viruses
Pichia
Proteus
Providencia
Pseudomonas
Psychrobacter
Raoultella
Salmonella
Serratia
Shigella
Streptococcus
Zymomonas
COGCOG2367
Description: Beta-lactamase class A
Function: Defense mechanisms;

NCBI CDD141062
Reference1) Sutcliffe JG, et al. (1978) Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.. Proc Natl Acad Sci U S A 75(8):3737-41 PubMed: 358200