ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Resistance Typebl2_kpc
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecarbapenem
cephalosporin
cephamycin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusCitrobacter
Enterobacter
Escherichia
Klebsiella
Pseudomonas
Salmonella
Serratia
NCBI CDD141062
Reference1) Yigit H, et al. (2001) Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.. Antimicrob Agents Chemother 45(4):1151-61 PubMed: 11257029