ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl2_ges
DescriptionClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecephalosporin
penicillin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAcinetobacter
Enterobacter
Escherichia
Klebsiella
Pseudomonas
NCBI CDD141062
Reference1) Poirel L, et al. (2000) Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.. Antimicrob Agents Chemother 44(3):622-32 PubMed: 10681329