ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl1_fox
DescriptionClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecephalosporin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAeromonas
Enterobacter
Escherichia
Klebsiella
COGCOG1680
Description: Beta-lactamase class C and other penicillin binding proteins
Function: Defense mechanisms;

NCBI CDD31866: AmpC
141062
Reference1) Gonzalez Leiza M, et al. (1994) Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.. Antimicrob Agents Chemother 38(9):2150-7 PubMed: 7811034