ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl1_asba
DescriptionClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecephalosporin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusAeromonas
COGCOG1680
Description: Beta-lactamase class C and other penicillin binding proteins
Function: Defense mechanisms;

NCBI CDD31866: AmpC
141062
Reference1) Rasmussen BA, et al. (1994) Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme.. Antimicrob Agents Chemother 38(9):2078-85 PubMed: 7811022