ARDB-Antibiotic Resistance Genes Database

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Resistance Typebl1_ampc
DescriptionClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Antibiotic Resistancecephalosporin
Gene Ontology (GO)Molecular Function
beta-lactamase activity [GO:0008800]


Biological Process
beta lactam resistance [AR:0000048]
drug enzymatic destruction [AR:0001004]
Found in GenusCitrobacter
Enterobacter
Enterococcus
Escherichia
Klebsiella
Kluyvera
COGCOG1680
Description: Beta-lactamase class C and other penicillin binding proteins
Function: Defense mechanisms;

NCBI CDD31866: AmpC
141062
Reference1) Galleni M, et al. (1988) Sequence and comparative analysis of three Enterobacter cloacae ampC beta-lactamase genes and their products.. Biochem J 250(3):753-60 PubMed: 3260487