ARDB-Antibiotic Resistance Genes Database

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Resistance Typearna
DescriptionBifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Antibiotic Resistancepolymyxin
Found in GenusCitrobacter
Escherichia
Salmonella
Shigella
COGCOG451
Description: Nucleoside-diphosphate-sugar epimerases
Function: Cell wall/membrane/envelope biogenesis; Carbohydrate transport and metabolism;

COG223
Description: Methionyl-tRNA formyltransferase
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD111763
142332
136634
140671
Reference1) Musso R, et al. (1977) Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli.. Proc Natl Acad Sci U S A 74(1):106-10 PubMed: 319453