ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph6ib
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistancestreptomycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusStreptomyces
NCBI CDD127421
Reference PubMed: 11083623
2) Vögtli M, et al. (1987) Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: nucleotide sequence and promoter analysis.. Mol Gen Genet 208(1-2):195-203 PubMed: 3039305
 PubMed: 8385262