ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph4ib
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistancehygromycin_b
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusStreptomyces
NCBI CDD142329
Reference PubMed: 11083623
 PubMed: 8385262
3) Zalacain M, et al. (1986) Nucleotide sequence of the hygromycin B phosphotransferase gene from Streptomyces hygroscopicus.. Nucleic Acids Res 14(4):1565-81 PubMed: 3005976